EVIDENCE FOR PRESYNAPTIC CHOLINERGIC RECEPTORS ON DOPAMINEGIC TERMINALS - DEGENERATION STUDIES WITH 6-HYDROXYDOPAMINE

被引：55
作者：
DEBELLEROCHE, J
LUGMANI, Y
BRADFORD, HF
机构：
[1] Department of Biochemistry, Imperial College, London
来源：
NEUROSCIENCE LETTERS | 1979年 / 11卷 / 02期
关键词：
D O I：
10.1016/0304-3940(79)90130-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intraventricular injections of 6-hydroxydopamine (6-OHDA) caused a significant decrease in the tyrosine hydroxylase of striatal synaptosomes of rats, without influencing GABA levels. Significant decreases in the muscarinic and nicotinic receptors also occurred in this preparation after 3 days. The receptors were measured by specific binding studies with N-methylatropine and α-bungarotoxin respectively. These results indicate that muscarinic and nicotinic receptors are located on the dopaminergic nerve terminals of corpus striatum. © 1979.
引用
收藏
页码：209 / 213
页数：5
相关论文
共 13 条
[1]   DISSOCIATION OF ALPHA-BUNGAROTOXIN BINDING AND RECEPTOR BLOCK IN RAT SUPERIOR CERVICAL GANGLION [J].
BROWN, DA ;
FUMAGALLI, L .
BRAIN RESEARCH, 1977, 129 (01) :165-168
[2]  
CHANG C. C., 1963, ARCH INTERNATL PHARMACODYN THER, V144, P241
[3]   BIOCHEMICAL EVIDENCE FOR PRESENCE OF PRESYNAPTIC RECEPTORS ON DOPAMINERGIC NERVE-TERMINALS [J].
DEBELLEROCHE, J ;
BRADFORD, HF .
BRAIN RESEARCH, 1978, 142 (01) :53-68
[4]   AUTOMATED SEPARATION AND ANALYSIS OF DOPAMINE, ITS AMINO-ACID PRECURSORS AND METABOLITES, AND APPLICATION OF METHOD TO MEASUREMENT OF SPECIFIC RADIOACTIVITIES OF DOPAMINE IN STRIATAL SYNAPTOSOMES [J].
DEBELLEROCHE, J ;
DYKES, CR ;
THOMAS, AJ .
ANALYTICAL BIOCHEMISTRY, 1976, 71 (01) :193-203
[5]  
DEBELLEROCHE JS, 1977, J NEUROCHEM, V29, P335
[6]  
DEBELLEROCHE JS, 1976, J NEUROCHEM, V26, P561
[7]   ALPHA-BUNGAROTOXIN, COBRA NEUROTOXIN AND EXCITATION OF RENSHAW CELLS BY ACETYLCHOLINE [J].
DUGGAN, AW ;
HALL, JG ;
LEE, CY .
BRAIN RESEARCH, 1976, 107 (01) :166-170
[8]   NICOTINIC CHOLINERGIC RECEPTOR IN BRAIN DETECTED BY BINDING OF ALPHA-[H-3]BUNGAROTOXIN [J].
ETEROVIC, VA ;
BENNETT, EL .
BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 362 (02) :346-355
[9]   NICOTINIC EFFECT OF ACETYLCHOLINE ON RELEASE OF NEWLY SYNTHESIZED [H-3] DOPAMINE IN RAT STRIATAL SLICES AND CAT CAUDATE-NUCLEUS [J].
GIORGUIEFF, MF ;
LEFLOCH, ML ;
WESTFALL, TC ;
GLOWINSKI, J ;
BESSON, MJ .
BRAIN RESEARCH, 1976, 106 (01) :117-131
[10]  
LOWRY J, 1976, BIOCHEMISTRY NY, V15, P1522
12