EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA ON BONE-MARROW MACROPHAGE IA EXPRESSION INDUCED BY CYTOKINES

被引：16
作者：
GOLLNICK, SO
CHENG, HL
GRANDE, CC
THOMPSON, D
TOMASI, TB
机构：
[1] ROSWELL PK CANC INST,DEPT MOLEC MED,BUFFALO,NY 14263
[2] CHILDRENS HOSP,MED CTR,HOWARD HUGHES MED INST,BOSTON,MA 02115
来源：
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1995年 / 15卷 / 05期
关键词：
D O I：
10.1089/jir.1995.15.485
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The initiation of the immune response is regulated, in part, by the effect of cytokines on the level of expression of major histocompatibility complex (MHC) class II antigens on antigen-presenting cells (APC). The expression of class II antigens on B cell and macrophage APC is induced by IFN-gamma and IL-4, and GM-CSF induces class II expression on macrophages (M phi). Our results show that transforming growth factor-beta (TGF-beta) inhibits IL-4- and GM-CSF-induced Ia gene expression on bone marrow macrophages but enhances IFN-gamma-induced gene expression. Nuclear run-on experiments demonstrated that the inhibitory effects of TGF-beta on GM-CSF- and IL-4-induced Ia antigen expression were primarily posttranscriptional and augmentation of IFN-gamma by TGF-beta was largely transcriptionally regulated.
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收藏
页码：485 / 491
页数：7
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