HOMEOBOX GENES AND HEART DEVELOPMENT

被引：26

作者：

KERN, MJ ^{[1
]}

ARGAO, EA ^{[1
]}

POTTER, SS ^{[1
]}

机构：

[1] UNIV CINCINNATI, COLL MED, CINCINNATI, OH 45267 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1995年 / 5卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/1050-1738(94)00033-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genes encoding transcription factors ave fundamental to developmental processes because their DNA-binding proteins can control expression of a multitude of genes. Therefore, activation of a single transcription factor gene can act as a genetic switch that controls the developmental destinies of groups of cells. Results of expression studies and mutational analyses in mice and Drosophila suggest an essential role in heart development for the homeobox class of transcription factor genes. Understanding the genetic circuitry of cardiogenesis will facilitate the identification of individuals with inherited cardiac diseases, and the possible prevention of these diseases with drug therapy or lifestyle modification. It may also allow for genetic counseling of affected individuals and family members and enable gene therapy aimed at correcting these defects.

引用

页码：47 / 54

页数：8

共 55 条

[31] DISRUPTION OF THE HOX-1.6 HOMEOBOX GENE RESULTS IN DEFECTS IN A REGION CORRESPONDING TO ITS ROSTRAL DOMAIN OF EXPRESSION [J].