MYC-MAX-MAD - A TRANSCRIPTION FACTOR NETWORK CONTROLLING CELL-CYCLE PROGRESSION, DIFFERENTIATION AND DEATH

被引：345
作者：
AMATI, B
LAND, H
机构：
[1] Imperial Cancer Research Fund, London
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 01期
关键词：
D O I：
10.1016/0959-437X(94)90098-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Myc oncoprotein dimerizes with its partner, Max, to bind DNA, activate transcription, and promote cell proliferation, as well as programmed cell death. Max also forms homodimers or heterodimers with its alternative partners, Mad and Mxi-1. These complexes behave as antagonists of Myc/Max through competition for common DNA targets, and perhaps permit cellular differentiation.
引用
收藏
页码：102 / 108
页数：7
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共 67 条
  • [1] THE C-MYC PROTEIN INDUCES CELL-CYCLE PROGRESSION AND APOPTOSIS THROUGH DIMERIZATION WITH MAX
    AMATI, B
    LITTLEWOOD, TD
    EVAN, GI
    LAND, H
    [J]. EMBO JOURNAL, 1993, 12 (13) : 5083 - 5087
  • [2] ONCOGENIC ACTIVITY OF THE C-MYC PROTEIN REQUIRES DIMERIZATION WITH MAX
    AMATI, B
    BROOKS, MW
    LEVY, N
    LITTLEWOOD, TD
    EVAN, GI
    LAND, H
    [J]. CELL, 1993, 72 (02) : 233 - 245
  • [3] TRANSCRIPTIONAL ACTIVATION BY THE HUMAN C-MYC ONCOPROTEIN IN YEAST REQUIRES INTERACTION WITH MAX
    AMATI, B
    DALTON, S
    BROOKS, MW
    LITTLEWOOD, TD
    EVAN, GI
    LAND, H
    [J]. NATURE, 1992, 359 (6394) : 423 - 426
  • [4] SEQUENCE-SPECIFIC TRANSCRIPTIONAL ACTIVATION BY MYC AND REPRESSION BY MAX
    AMIN, C
    WAGNER, AJ
    HAY, N
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (01) : 383 - 390
  • [5] ORNITHINE DECARBOXYLASE ACTIVITY IS CRITICAL FOR CELL-TRANSFORMATION
    AUVINEN, M
    PAASINEN, A
    ANDERSSON, LC
    HOLTTA, E
    [J]. NATURE, 1992, 360 (6402) : 355 - 358
  • [6] MAD - A HETERODIMERIC PARTNER FOR MAX THAT ANTAGONIZES MYC TRANSCRIPTIONAL ACTIVITY
    AYER, DE
    KRETZNER, L
    EISENMAN, RN
    [J]. CELL, 1993, 72 (02) : 211 - 222
  • [7] A SWITCH FROM MYC-MAX TO MAD-MAX HETEROCOMPLEXES ACCOMPANIES MONOCYTE/MACROPHAGE DIFFERENTIATION
    AYER, DE
    EISENMAN, RN
    [J]. GENES & DEVELOPMENT, 1993, 7 (11) : 2110 - 2119
  • [8] BARNER M, 1992, CELL GROWTH DIFFER, V3, P183
  • [9] ACTIVATION DOMAINS OF L-MYC AND C-MYC DETERMINE THEIR TRANSFORMING POTENCIES IN RAT EMBRYO CELLS
    BARRETT, J
    BIRRER, MJ
    KATO, GJ
    DOSAKAAKITA, H
    DANG, CV
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (07) : 3130 - 3137
  • [10] INTERACTIONS OF COILED COILS IN TRANSCRIPTION FACTORS - WHERE IS THE SPECIFICITY
    BAXEVANIS, AD
    VINSON, CR
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1993, 3 (02) : 278 - 285
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