THE ORDER AND ORIENTATION OF A CLUSTER OF METALLOPROTEINASE GENES, STROMELYSIN-2, COLLAGENASE, AND STROMELYSIN, TOGETHER WITH D11S385, ON CHROMOSOME-11Q22-Q23

被引：25
作者：
FORMSTONE, CJ
BYRD, PJ
AMBROSE, HJ
RILEY, JH
HERNANDEZ, D
MCCONVILLE, CM
TAYLOR, AMR
机构：
[1] UNIV BIRMINGHAM,SCH MED,CANC RES CAMPAIGN LABS,DEPT CANC STUDIES,POB 363,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
[2] ICI PLC,PHARMACEUT,DEPT BIOTECHNOL,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND
来源：
GENOMICS | 1993年 / 16卷 / 01期
关键词：
D O I：
10.1006/geno.1993.1181
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A cluster of metalloproteinase genes, stromelysin, fibroblast collagenase, and stromelysin 2 together with the anonymous DNA marker D11S385, was mapped using pulsed-field gel electrophoresis to a 135-kb region of chromosome 11q22-q23. The physical proximity of these markers was subsequently confirmed using two YAC clones, and their relative order was established as stromelysin 2-collagenase-stromelysin-D11S385. The pattern of marker representation in a panel of radiation-reduced chromosome 11 hybrids suggests that the metalloproteinase gene/D11S385 cluster is orientated with STMY2 closest to the centromere. © 1993 by Academic Press, Inc.
引用
收藏
页码：289 / 291
页数：3
相关论文
共 11 条
  • [1] COLLIER IE, 1988, J BIOL CHEM, V263, P10711
  • [2] SEGREGATION OF THE HUNTINGTON DISEASE REGION OF HUMAN-CHROMOSOME 4 IN A SOMATIC-CELL HYBRID
    COX, DR
    PRITCHARD, CA
    UGLUM, E
    CASHER, D
    KOBORI, J
    MYERS, RM
    [J]. GENOMICS, 1989, 4 (03) : 397 - 407
  • [3] LOCALIZATION OF AN ATAXIA-TELANGIECTASIA GENE TO CHROMOSOME 11Q22-23
    GATTI, RA
    BERKEL, I
    BODER, E
    BRAEDT, G
    CHARMLEY, P
    CONCANNON, P
    ERSOY, F
    FOROUD, T
    JASPERS, NGJ
    LANGE, K
    LATHROP, GM
    LEPPERT, M
    NAKAMURA, Y
    OCONNELL, P
    PATERSON, M
    SALSER, W
    SANAL, O
    SILVER, J
    SPARKES, RS
    SUSI, E
    WEEKS, DE
    WEI, S
    WHITE, R
    YODER, F
    [J]. NATURE, 1988, 336 (6199) : 577 - 580
  • [4] A DETAILED GENETIC-MAP OF THE LONG ARM OF CHROMOSOME-11
    JULIER, C
    NAKAMURA, Y
    LATHROP, M
    OCONNELL, P
    LEPPERT, M
    LITT, M
    MOHANDAS, T
    LALOUEL, JM
    WHITE, R
    [J]. GENOMICS, 1990, 7 (03) : 335 - 345
  • [5] JUNG JY, 1990, ANN GENET-PARIS, V33, P21
  • [6] GENETICS OF SOMATIC MAMMALIAN-CELLS .20. GENETICS OF SOMATIC MAMMALIAN-CELLS - GENETIC, IMMUNOLOGICAL, AND BIOCHEMICAL ANALYSIS WITH CHINESE-HAMSTER CELL HYBRIDS CONTAINING SELECTED HUMAN CHROMOSOMES
    KAO, FT
    JONES, C
    PUCK, TT
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (01) : 193 - 197
  • [7] FINE MAPPING OF THE CHROMOSOME-11Q22-23 REGION USING PFGE, LINKAGE AND HAPLOTYPE ANALYSIS - LOCALIZATION OF THE GENE FOR ATAXIA TELANGIECTASIA TO A 5CM REGION FLANKED BY NCAM/DRD2 AND STMY/CJ52.75, PHI-2.22
    MCCONVILLE, CM
    FORMSTONE, CJ
    HERNANDEZ, D
    THICK, J
    TAYLOR, AMR
    [J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (15) : 4335 - 4343
  • [8] THE COLLAGENASE GENE FAMILY IN HUMANS CONSISTS OF AT LEAST 4 MEMBERS
    MULLER, D
    QUANTIN, B
    GESNEL, MC
    MILLONCOLLARD, R
    ABECASSIS, J
    BREATHNACH, R
    [J]. BIOCHEMICAL JOURNAL, 1988, 253 (01) : 187 - 192
  • [9] CLONING OF THE GENES FOR HUMAN STROMELYSIN AND STROMELYSIN .2. DIFFERENTIAL EXPRESSION IN RHEUMATOID SYNOVIAL FIBROBLASTS
    SIRUM, KL
    BRINCKERHOFF, CE
    [J]. BIOCHEMISTRY, 1989, 28 (22) : 8691 - 8698
  • [10] SOBEL E, 1992, AM J HUM GENET, V50, P1343
12