ERYTHROMYCIN INHIBITION OF LIPOPOLYSACCHARIDE-STIMULATED TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION BY HUMAN MONOCYTES INVITRO

被引：61

作者：

IINO, Y

TORIYAMA, M

NATORI, Y

KUDO, K

YUO, A

机构：

[1] NATL MED CTR, INST CLIN RES, TOKYO, JAPAN

[2] NATL MED CTR, DEPT OTOLARYNGOL, TOKYO, JAPAN

[3] NATL MED CTR, DEPT RESP DIS, TOKYO, JAPAN

来源：

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | 1992年 / 101卷 / 10期

关键词：

ERYTHROMYCIN; LIPOPOLYSACCHARIDE; MONOCYTES; SINOBRONCHIAL SYNDROME; TUMOR-NECROSIS-FACTOR-ALPHA;

D O I：

10.1177/0003489492101S1005

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The mechanism of clinical effectiveness of low-dose and long-term erythromycin (EM) treatment for diffuse panbronchiolitis, sinobronchial syndrome, and associated otitis media with effusion was investigated by studying the effects of EM on tumor necrosis factor alpha (TNF-alpha) production by cultured human monocytes stimulated with lipopolysaccharide. At concentrations of 0.1 mug/mL or more, EM inhibited TNF-alpha release from human monocytes stimulated by lipopolysaccharide in a dose-dependent manner. Of the other macrolides tested, roxithromycin, an EM derivative, also showed significant inhibition of TNF-alpha production, where as josamycin failed to inhibit TNF-alpha release from monocytes. Nonmacrolidic drugs such as minocycline hydrochloride, ofloxacin, or penicillin G had no significant effect on TNF-alpha production. These results suggest that the clinical improvement of chronic respiratory diseases by EM may depend on the suppression of production of inflammatory cytokines such as TNF-alpha.

引用

页码：16 / 20

页数：5

共 23 条

[1] EFFECTS OF 2 ERYTHROMYCINS, DOXYCYCLINE AND PHENOXYMETHYLPENICILLIN ON HUMAN-LEUKOCYTE CHEMOTAXIS INVITRO [J].