MODULATION BY NOVOBIOCIN OF SISTER-CHROMATID EXCHANGES INDUCED BY TUMOR-NECROSIS-FACTOR IN HUMAN-LYMPHOCYTES

被引：15
作者：
LAZUTKA, JR
RUDAITIENE, S
机构：
[1] Ecological Genetics Laboratory, Vilnius University
来源：
MUTATION RESEARCH | 1992年 / 268卷 / 02期
关键词：
NOVOBIOCIN; TUMOR NECROSIS FACTOR; SISTER-CHROMATID EXCHANGE; HUMAN LYMPHOCYTES;
D O I：
10.1016/0027-5107(92)90227-S
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The effect of the antibiotic novobiocin on human recombinant tumor necrosis factor (TNF)-induced sister-chromatid exchanges (SCEs) were examined in human peripheral blood lymphocytes. TNF, when introduced in a dose range of 10-1000 U/ml at the initiation of culture, was found to cause a significant increase in SCE frequency. The simultaneous addition of TNF and novobiocin (25-mu/ml) in the assay resulted in no increase of SCE frequency. Delayed (for 24 h) addition of novobiocin suppressed the induction of SCEs by 50, 100 and 500 U/ml but not by 1000 U/ml of TNF.
引用
收藏
页码：217 / 221
页数：5
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