THE INFLUENCE OF ASCORBIC-ACID ON LIPID-PEROXIDATION IN GUINEA-PIGS INTOXICATED WITH CADMIUM

被引：47
|
作者：
HUDECOVA, A
GINTER, E
机构：
[1] Institute of Preventive and Clinical Medicine, 833 01 Bratislava
来源：
FOOD AND CHEMICAL TOXICOLOGY | 1992年 / 30卷 / 12期
关键词：
D O I：
10.1016/0278-6915(92)90111-W
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Cadmium (as CdCl2) administered at a dose of 1 mg Cd/animal/day in drinking water to guinea pigs with a low intake of ascorbic acid (2 mg/animal/day) increased lipid peroxidation (LPO) in the kidney, liver and serum after 5 wk of treatment. A high intake of ascorbic acid (100 mg/animal/day) decreased LPO (determined from malondialdehyde levels) in the kidney, liver and serum of Cd-treated guinea pigs. Administration of Cd to guinea pigs with a low intake of ascorbic acid significantly increased LPO in the kidney at 5 wk, in comparison with controls given low levels of ascorbic acid but no Cd. However, at 12 wk, LPO in the kidney of Cd-treated guinea pigs was significantly lower than in the controls. These results indicate that the level of lipid peroxides in the kidney of guinea pigs with a low intake of ascorbic acid depends on the amount of accumulated cadmium.
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页码：1011 / 1013
页数：3
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