Clinical research design and causality: does oral rotavirus vaccine cause intussusception?

被引：0

作者：

Fernanda Castilla-Peon, Maria ^{[1
]}

Ramirez-Sandoval, Juan C. ^{[2
]}

Reyes-Morales, Hortensia ^{[3
]}

Reyes-Lopez, Alfonso ^{[3
]}

机构：

[1] Hosp Infantil Mexico Fed Gomez, Dept Ediciones Med, Mexico City, DF, Mexico

[2] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nefrol & Metab Mineral, Mexico City, DF, Mexico

[3] Hosp Infantil Mexico Fed Gomez, Direcc Invest, Mexico City, DF, Mexico

来源：

BOLETIN MEDICO DEL HOSPITAL INFANTIL DE MEXICO | 2015年 / 72卷 / 05期

关键词：

Research designs; Causality; Clinical trial; Cohort; Case-control; Cross-sectional;

D O I：

10.1016/j.bmhimx.2015.09.005

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Design of clinical research whose purpose is to answer questions about causality can be classified in relation to four axes: the number of study groups, the implementation of an experimental maneuver, cause-effect directionality and source from which the data are collected. The basic designs used in epidemiology are the clinical trial, the cohort study, the case-control study and the cross-sectional survey. This text aims to facilitate the identification and understanding of each of these designs through examples related to the association between rotavirus vaccination and intussusception. (C) 2015 Hospital Infantil de Mexico Federico Gomez. Published by Masson Doyma Mexico S.A.

引用

页码：346 / 352

页数：7