Serum cholesterol and LDL-C in association with level of diastolic blood pressure in type 2 diabetic patients

Introduction: Elevated cholesterol and blood pressure are major risk factors for the development diabetic kidney disease. Possible interactions between these two parameters have not been studied in detail. Objectives: This investigation aims to study the values of blood serum cholesterol, blood pressure and possible correlations between them, in a group of type 2 diabetic (T2D) patients. Patients and Methods: A total of 60 patients with T2D were enrolled to the study. Venous blood samples were obtained in the fasting state for determinations of serum creatinine, lipids and hemoglobin A(1C) (HbA(1c)). Results: Of 60 participants, Mean of age was 57 +/- 8.3 years. Mean of systolic and diastolic blood pressure was 133 +/- 13 mmHg and 84 +/- 7.4 mmHg respectively. Mean of serum cholesterol and LDL-C was 182 +/- 34.5 mg/dl and 97.2 +/- 27.9 mg/dl respectively. In this study, a significant positive correlation of serum cholesterol with level of diastolic blood pressure (r= 0.286, p=0.030) was seen (adjusted for duration of diabetes and weight). Furthermore a significant positive correlation of serum LDL-C with level of diastolic blood pressure (r= 0.263, p= 0.044) was seen (adjusted for age). Conclusion: We found a significant inverse correlation of serum cholesterol and LDL-C with level of diastolic blood pressure. This study showed the influence of serum lipids on the development of hypertension and further support the control of dyslipidemia, to prevent diabetic kidney disease.