Dietary Flavonoids: Molecular Mechanisms of Action as Anti-Inflammatory Agents

被引：140
作者：
Marzocchella, Laura [1 ]
Fantini, Massimo [1 ]
Benvenuto, Monica [1 ]
Masuelli, Laura [2 ]
Tresoldi, Ilaria [1 ]
Modesti, Andrea [1 ]
Bei, Roberto [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Via Montpellier 1, I-00133 Rome, Italy
[2] Univ Rome Sapienza, Dept Expt Med, Rome, Italy
来源：
RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY | 2011年 / 5卷 / 03期
关键词：
Bioavailability; flavonoids; fruit; inflammation;
D O I：
10.2174/187221311797264937
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Flavonoids are a large group of polyphenolic compounds, which are ubiquitously expressed in plants. They are grouped according to their chemical structure and function into flavonols, flavones, flavan-3-ols, anthocyanins, flavanones and isoflavones. Many of flavonoids are found in fruits, vegetables and beverages. Flavonoids have been demonstrated to have advantageous effects on human health because their anti-allergic, anti-inflammatory, anti-platelet aggregation, antitumor and anti-oxidant behavior. This report reviews the current knowledge on the molecular mechanisms of action of flavonoids as anti-inflammatory agents and also discusses the relevant patents.
引用
收藏
页码：200 / 220
页数：21
相关论文
共 293 条
[1]   Dietary flavonols: Chemistry, food content, and metabolism [J].
Aherne, SA ;
O'Brien, NM .
NUTRITION, 2002, 18 (01) :75-81
[2]   Epigal locatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production [J].
Ahmed, Salahuddin ;
Marotte, Hubert ;
Kwan, Kevin ;
Ruth, Jeffrey H. ;
Campbell, Phillip L. ;
Rabquer, Bradley J. ;
Pakozdi, Angela ;
Koch, Alisa E. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) :14692-14697
[3]   Epigallocatechin-3-O-gallate inhibits TNFα-induced monocyte chemotactic protein-1 production from vascular endothelial cells [J].
Ahn, Hee Yul ;
Xu, Yi ;
Davidge, Sandra T. .
LIFE SCIENCES, 2008, 82 (17-18) :964-968
[4]  
Andriamanalijaona R, 2005, J RHEUMATOL, V32, P1958
[5]  
[Anonymous], 2003, USDA DATABASE FLAVON
[6]  
Arai Y, 2000, J NUTR, V130, P2243
[7]   Flavan-3-ols: Nature, occurrence and biological activity [J].
Aron, Patricia M. ;
Kennedy, James A. .
MOLECULAR NUTRITION & FOOD RESEARCH, 2008, 52 (01) :79-104
[8]   Catechin intake and associated dietary and lifestyle factors in a representative sample of Dutch men and women [J].
Arts, ICW ;
Hollman, PCH ;
Feskens, EJM ;
de Mesquita, HBB ;
Kromhout, D .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2001, 55 (02) :76-81
[9]   Inhibition of nitric oxide synthase expression by a methanolic extract of Crescentia alata and its derived flavonols [J].
Autore, G ;
Rastrelli, L ;
Lauro, MR ;
Marzocco, S ;
Sorrentino, R ;
Sorrentino, U ;
Pinto, A ;
Aquino, R .
LIFE SCIENCES, 2001, 70 (05) :523-534
[10]   (-)Epigallocatechin gallate hampers collagen destruction and collagenase activation in ultraviolet-B-irradiated human dermal fibroblasts: Involvement of mitogen-activated protein kinase [J].
Bae, Ji-Young ;
Choi, Jung-Suk ;
Choi, Yean-Jung ;
Shin, Seung-Yong ;
Kang, Sang-Wook ;
Han, Seoung Jun ;
Kang, Young-Hee .
FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (04) :1298-1307
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