The small intestinal mucosa and its stem cells

被引：2

作者：

Ambu, Rossano ^{[1
]}

Gerosa, Clara ^{[1
]}

Locci, Giorgia ^{[1
]}

Obinu, Eleonora ^{[1
]}

Ravarino, Alberto ^{[1
]}

De Magistris, Anna ^{[2
,3
,4
]}

Reali, Alessandra ^{[2
,3
,4
]}

Van Eyken, Peter ^{[5
]}

Faa, Gavino ^{[1
]}

Nati, Silvia ^{[1
]}

Vinci, Laura ^{[1
]}

机构：

[1] Univ Cagliari, Div Pathol, Dept Surg Sci, Cagliari, Italy

[2] AOU, Inst Puericulture, Neonatal Pathol, Neonatal Intens Care Unit, Cagliari, Italy

[3] AOU, Neonatal Sect, Cagliari, Italy

[4] Univ Cagliari, Cagliari, Italy

[5] Ziekenhuis Oost Limburg, Dept Pathol, Genk, Belgium

来源：

JOURNAL OF PEDIATRIC AND NEONATAL INDIVIDUALIZED MEDICINE | 2016年 / 5卷 / 02期

关键词：

Small intestinal mucosa; embryogenesis; crypt-villus axis; stem cells; signaling pathways; regenerative medicine;

D O I：

10.7363/050224

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In the first part of this review a brief summary of the embryology and histology of the gastrointestinal tract is provided. In the second part intestinal stem cells (ISCs) are discussed. Several signaling pathways play a crucial role in the crypt base in the regulation of ISC proliferation and self-renewal; Wnt, Notch, BMP, Ephrin, JAK/STAT1, PTEN, AKT, PI3K and many more. Numerous investigators are involved in studying the location, number, and behavior of ISCs within the base of the intestinal crypts. Several markers are espressed by ISCs. Among these, Leucine-rich-repeat-containing G-protein-coupled receptor-5 (Lgr5), Sox9, Prominin-1, DCAMKL-1, EphB2, p-PTEN, p-AKT, Fgfr3, m-TER, and CD44. Stem cell therapy has shown promise for the treatment of some diseases characterized by tissue damage with ischemic and inflammatory lesions like inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC).

引用

页数：9

共 43 条

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