EFFECT OF VARIOUS POTENTIAL INHIBITORS, ACTIVATORS AND INDUCERS ON THE N-OXIDATION OF 3-SUBSTITUTED PYRIDINES INVITRO

被引：43

作者：

GORROD, JW

DAMANI, LA

机构：

[1] Department of Pharmacy, Chelsea College, University of London, London, SW3 6LX, Manresa Road

[2] Department of Pharmacy, University of Manchester, Manchester

来源：

XENOBIOTICA | 1979年 / 9卷 / 04期

关键词：

D O I：

10.3109/00498257909038724

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The N-oxidation of pyridine, 3-methylpyridine and 3-chloropyridine was inhibited by SKF 525A and DPEA. The C-oxidation of 3-methylpyridine was also inhibited by these compounds. 2. The N-oxidation of these pyridines was also inhibited by various other nitrogenous substrates including n-octylamine. 3. Incubation in an atmosphere of carbon monoxide resulted in inhibition of both C- and N-oxidation of 3-methylpyridine. 4. Any treatment of microsomes which resulted in a reduction of cytochrome P-450 also produced a concomitant fall in N-oxidation of the pyridines. 5. Pretreatment of animals with phenobarbitone resulted in an increase in the N-oxidation of the pyridines. Pretreatment with 3-methylcholanthrene had no appreciable effect on the N-oxidation of the pyridines in vitro. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：219 / 226

页数：8