EFFECT OF VARIOUS POTENTIAL INHIBITORS, ACTIVATORS AND INDUCERS ON THE N-OXIDATION OF 3-SUBSTITUTED PYRIDINES INVITRO

被引：43
作者：
GORROD, JW
DAMANI, LA
机构：
[1] Department of Pharmacy, Chelsea College, University of London, London, SW3 6LX, Manresa Road
[2] Department of Pharmacy, University of Manchester, Manchester
来源：
XENOBIOTICA | 1979年 / 9卷 / 04期
关键词：
D O I：
10.3109/00498257909038724
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The N-oxidation of pyridine, 3-methylpyridine and 3-chloropyridine was inhibited by SKF 525A and DPEA. The C-oxidation of 3-methylpyridine was also inhibited by these compounds. 2. The N-oxidation of these pyridines was also inhibited by various other nitrogenous substrates including n-octylamine. 3. Incubation in an atmosphere of carbon monoxide resulted in inhibition of both C- and N-oxidation of 3-methylpyridine. 4. Any treatment of microsomes which resulted in a reduction of cytochrome P-450 also produced a concomitant fall in N-oxidation of the pyridines. 5. Pretreatment of animals with phenobarbitone resulted in an increase in the N-oxidation of the pyridines. Pretreatment with 3-methylcholanthrene had no appreciable effect on the N-oxidation of the pyridines in vitro. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：219 / 226
页数：8
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