C/EBP-ALPHA - A CRITICAL REGULATOR OF GENES GOVERNING INTEGRATIVE METABOLIC PROCESSES

The role of C/EBP alpha in the developmental expression of a subset of genes governing essential metabolic processes has recently been elucidated using a mutant mouse model that lacks this transcription factor. The mutation results in a failure of the liver and white and brown adipose tissue to develop normal metabolic functions in the immediate perinatal period, including hepatic glycogen synthesis and gluconeogenesis and the synthesis and deposition of triglyceride in adipose tissue. These metabolic alterations are very similar to those of human infants born prior to the third trimester and suggest that many of the medical complications of prematurity are a result of the tack of activation of C/EBP alpha in development.