C/EBP-ALPHA - A CRITICAL REGULATOR OF GENES GOVERNING INTEGRATIVE METABOLIC PROCESSES

被引：111
作者：
DARLINGTON, GJ
WANG, N
HANSON, RW
机构：
[1] BAYLOR COLL MED,DEPT MOLEC & HUMAN GENET,HOUSTON,TX 77030
[2] CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 05期
关键词：
D O I：
10.1016/0959-437X(95)80024-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The role of C/EBP alpha in the developmental expression of a subset of genes governing essential metabolic processes has recently been elucidated using a mutant mouse model that lacks this transcription factor. The mutation results in a failure of the liver and white and brown adipose tissue to develop normal metabolic functions in the immediate perinatal period, including hepatic glycogen synthesis and gluconeogenesis and the synthesis and deposition of triglyceride in adipose tissue. These metabolic alterations are very similar to those of human infants born prior to the third trimester and suggest that many of the medical complications of prematurity are a result of the tack of activation of C/EBP alpha in development.
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页码：565 / 570
页数：6
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