TREATMENT OF GUILLAIN-BARRE-SYNDROME WITH HIGH-DOSE IMMUNE GLOBULINS COMBINED WITH METHYLPREDNISOLONE - A PILOT-STUDY

被引:0
作者
VISSER, LH
SCHMITZ, PIM
VANDOORN, PA
VANDERMECHE, FGA
MEULSTEE, J
DEJAGER, AEJ
VANDENHOVEN, RM
PRICK, MJJ
FRENKEN, CWGM
VERHAGEN, WIM
VANDENBRAND, HJ
SINNIGE, HAW
ARTS, WFM
DEWEERD, AW
LEIJTEN, F
KLEYWEG, RP
VANLEUSDEN, JA
VERSCHUREN, J
VANDERHEIJDENMONTFROY, A
OPDECOUL, AAW
SCHELLENS, RLAA
机构
[1] CANISINS WILHELMINA ZIEKENHUIS,NIJMEGEN,NETHERLANDS
[2] ST CLARA HOSP,ROTTERDAM,NETHERLANDS
[3] WESTEINDE ZIEKENHUIS,THE HAGUE,NETHERLANDS
[4] MERWEDE ZIEKENHUIS,DORDRECHT,NETHERLANDS
[5] MED CTR,ALKMAR,NETHERLANDS
[6] ACAD ZICKENHUIS,MAASTRICHT,NETHERLANDS
[7] ST ELIZABETH HOSP,TILBURG,NETHERLANDS
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中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In an open study 25 patients with Guillain-Barre syndrome were treated for 5 days with intravenous immune globulins in a dose of 0.4 gm/kg of body weight/day and 0.5 gm of methylprednisolone intravenously per day. The results of this combined treatment were compared with the results from. a group of 74 patients who were treated with immune globulins only in a recent Dutch Guillain-Barre trial. In the methylprednisolone-immune globulin treatment group, 19 of 25 patients (76%) improved by one or more functional grades after 4 weeks, as compared with 39 (53%) of 74 patients treated with immune globulin alone (p = 0;04). Also the median time required to the stage of walking independently was reduced in the methylprednisolone-immune globulin treatment group. This pilot study suggests that combined treatment with methylprednisolone and immune globulins in patients with the Guillain-Barre syndrome is more effective than treatment with immune globulins alone; a randomized clinical trial might confirm this.
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页码:749 / 752
页数:4
相关论文
共 12 条
  • [11] 1993, LANCET, V341, P586
  • [12] 1985, NEUROLOGY, V35, P1096