SUSCEPTIBILITY OF MELANIZED AND NONMELANIZED CRYPTOCOCCUS-NEOFORMANS TO NITROGEN-DERIVED AND OXYGEN-DERIVED OXIDANTS

被引：185
作者：
WANG, YL
CASADEVALL, A
机构：
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED,DIV INFECT DIS,BRONX,NY 10461
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL,BRONX,NY 10461
来源：
INFECTION AND IMMUNITY | 1994年 / 62卷 / 07期
关键词：
D O I：
10.1128/IAI.62.7.3004-3007.1994
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Melanized Cryptococcus neoformans cells were less susceptible than nonmelanized cells to the fungicidal effects of nitrogen- and oxygen-derived oxidants. The results support the hypothesis that the phenoloxidase enzyme system contributes to virulence by protecting C. neoformans against nitrogen- and oxygen-derived oxidative antimicrobial molecules produced by immune effector cells.
引用
收藏
页码：3004 / 3007
页数：4
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