LACK OF CORRELATION BETWEEN THE NUMBER OF CIRCULATING B-CELLS AND THE CONCENTRATION OF SERUM ANTIBODIES REACTIVE WITH THE HIV-1 ENVELOPE GLYCOPROTEIN

被引:0
作者
SCHWARTZ, DH
COSENTINO, LM
SHIRAI, A
CONOVER, J
DANIEL, S
KLINMAN, DM
机构
[1] CBER,FDA,DIV VIROL,RETROVIRAL RES LAB,BETHESDA,MD 20892
[2] JOHNS HOPKINS UNIV,SCH PUBL HLTH,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD
来源
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY | 1994年 / 7卷 / 05期
关键词
HIV-1; GP160; B CELLS; IMMUNE RESPONSE; SERUM ANTIBODIES;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cells obtained from the peripheral blood of HIV-infected patients and volunteers immunized with HIV-I vaccines are commonly used to study anti-viral responses, since lymphocytes from the central lymphoid organs are difficult to obtain. Analyses involving PBMC implicitly assume that circulating B cells provide an accurate reflection of the systemic humoral response induced by the HIV antigens. We examined this assumption by comparing the number of B cells secreting IgG anti-gp160/120 antibodies in the peripheral circulation with serum antibody titers. Results indicate that neither the magnitude nor duration of the serologic response detected in HIV-infected patients or gp160/gp 120-immunized volunteers reproducibly correlates with the number of B cells secreting anti-envelope antibodies in the blood.
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页码:447 / 453
页数:7
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