A SYNTHETIC APPROACH TO THE C26-C32 FRAGMENT OF RAPAMYCIN - A SYNTHESIS OF ALLYLIC ALCOHOLS FROM ALLYLIC FURYLSILANES

被引：0
作者：
NORLEY, MC
KOCIENSKI, PJ
FALLER, A
机构：
[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,YEW TREE BOTTOM RD,EPSOM KT18 5XQ,SURREY,ENGLAND
来源：
SYNLETT | 1994年 / 01期
关键词：
RAPAMYCIN; FLEMING-TAMAO OXIDATION; FURAN PHOTOOXIDATION; SILYLSTANNYLATION; IRELAND-CLAISEN REARRANGEMENT;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Key steps in a synthesis of the C23-C32 fragment of rapamycin include a regioselective Pd(0)-catalysed silylstannylation of an alkyne; a Pd(0)-catalysed coupling of a (Z)-2-silyl-1-stannylalkene with an acid choride; and a Fleming-Tamao oxidation of an allylic silanol generated by photo-oxidation of an allylic furyldimethylsilane.
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页码：77 / 78
页数：2
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