INVITRO SYNERGISTIC ACTIVITY BETWEEN OFLOXACIN AND ANSAMYCIN AGAINST MYCOBACTERIUM-LEPRAE

被引：0

作者：

DHOPLE, AM ^{[1
]}

IBANEZ, MA ^{[1
]}

GARDNER, GD ^{[1
]}

机构：

[1] HOLMES REG MED CTR,MELBOURNE,FL

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1993年 / 43-1卷 / 03期

关键词：

ANSAMYCINS; MYCOBACTERIUM-LEPRAE; OFLOXACIN; INVITRO STUDIES; RIFABUTIN; RIFAMPICIN;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antimicrobial effects of ofloxacin, alone and in combination with either rifampicin or rifabutin, were evaluated against M. leprae, using in vitro cell-free culture system. The minimum inhibitory concentration (MIC) of ofloxacin against M. leprae was 15 mug/ml, while MICs of rifampicin and rifabutin were 0.4 and 0.2 mug/ml, respectively. Combination of 0.375 mug/ml ofloxacin and 0.05 mug/ml of rifabutin exhibited synergistic bactericidal activity while the effect of combination of 0.75 mug/ml ofloxacin and 0.2 mug/ml rifampicin was additive bactericidal. Thus, combination of ofloxacin and rifabutin deserves further attention in multi-drug therapy of leprosy.

引用

页码：384 / 386

页数：3