CHRONIC NO SYNTHASE INHIBITION FAILS TO PROTECT HIPPOCAMPAL-NEURONS AGAINST NMDA TOXICITY

被引：42

作者：

LERNERNATOLI, M ^{[1
]}

RONDOUIN, G ^{[1
]}

DEBOCK, F ^{[1
]}

BOCKAERT, J ^{[1
]}

机构：

[1] CTR CNRS,INSERM PHARMACOL ENDOCRINOL,F-34094 MONTPELLIER 5,FRANCE

来源：

NEUROREPORT | 1992年 / 3卷 / 12期

关键词：

NITRIC OXIDE; N-METHYL-D-ASPARTATE; HIPPOCAMPUS; TOXICITY; NG-NITRO-L-ARGININE METHYL ESTER; L-NG-NITROARGININE; RAT;

D O I：

10.1097/00001756-199212000-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SINCE nitric oxide (NO) is supposed to mediate excitotoxicity in various brain structures, the effects of two NO synthase inhibitors were studied on rat hippocampal lesions induced by the focal injection of N-methyl-D-aspartate (NMDA). Although both drugs (N(G)-nitro-L-arginine methyl ester: L-NAME and L-N(G)-nitroarginine: L-NOARG) were given twice daily for 4 days before NMDA injection, at doses which are known to profoundly inhibit NO synthase activity, no significant decrease of NMDA-induced damage could be observed. These results do not confirm the current hypothesis of a NO involvement in NMDA toxicity at least on hippocampal neurons, in vivo.

引用

页码：1109 / 1112

页数：4

共 24 条

[1]

ALBEFESSARD D, 1966, ATLAS STEREOTAXIQUE

[2] GLUCOCORTICOID ENDANGERMENT OF HIPPOCAMPAL-NEURONS IS NMDA-RECEPTOR DEPENDENT [J].

ARMANINI, MP ;

HUTCHINS, C ;

STEIN, BA ;

SAPOLSKY, RM .

BRAIN RESEARCH, 1990, 532 (1-2) :7-12

[3] LOCALIZATION OF NITRIC-OXIDE SYNTHASE INDICATING A NEURAL ROLE FOR NITRIC-OXIDE [J].

BREDT, DS ;

HWANG, PM ;

SNYDER, SH .

NATURE, 1990, 347 (6295) :768-770

[4]

BREDT DS, 1991, NATURE, V351, P741

[5] SODIUM-NITROPRUSSIDE DEGENERATES CULTURED RAT STRIATAL NEURONS [J].

CHEN, J ;

CHANG, B ;

WILLIAMS, M ;

MURAD, F .

NEUROREPORT, 1991, 2 (03) :121-123

[6] GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].

CHOI, DW .

NEURON, 1988, 1 (08) :623-634

[7]

DANIELL LC, 1988, J PHARMACOL EXP THER, V245, P1

[8] NITRIC-OXIDE MEDIATES GLUTAMATE NEUROTOXICITY IN PRIMARY CORTICAL CULTURES [J].

DAWSON, VL ;

DAWSON, TM ;

LONDON, ED ;

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) :6368-6371

[9] ABSENCE OF IMPLICATION OF L-ARGININE/NITRIC OXIDE PATHWAY ON NEURONAL CELL INJURY INDUCED BY L-GLUTAMATE OR HYPOXIA [J].

DEMERLEPALLARDY, C ;

LONCHAMPT, MO ;

CHABRIER, PE ;

BRAQUET, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (01) :456-464

[10] NMDA RECEPTOR ACTIVATION IN RAT HIPPOCAMPUS INDUCES CYCLIC-GMP FORMATION THROUGH THE L-ARGININE NITRIC-OXIDE PATHWAY [J].

EAST, SJ ;

GARTHWAITE, J .

NEUROSCIENCE LETTERS, 1991, 123 (01) :17-19

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