SIMULTANEOUS DETERMINATION OF COMMON BENZODIAZEPINES IN BLOOD USING CAPILLARY GAS-CHROMATOGRAPHY

被引：37

作者：

GJERDE, H ^{[1
]}

DAHLIN, E ^{[1
]}

CHRISTOPHERSEN, AS ^{[1
]}

机构：

[1] NATL INST FORENS TOXICOL,POB 16 GAUSTAD,N-0320 OSLO,NORWAY

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 05期

关键词：

BENZODIAZEPINES; BLOOD; CAPILLARY GAS CHROMATOGRAPHY;

D O I：

10.1016/0731-7085(92)80046-P

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Blood samples were extracted with n-butyl acetate, and the extracts analysed by capillary gas chromatography using DB-1 and DB-1701 capillary columns with electron-capture detection. The DB-1701 column was found to give better separation of different benzodiazepines (BZDs). Recoveries ranged from 79 to 98%. Detection limits ranged from 0.005 to 0.015-mu-M for triazolam and flunitrazepam, and from 0.02 to 0.1-mu-M for other BZDs. Data on accuracy and precision are given for diazepam, desmethyldiazepam, flunitrazepam and nitrazepam.

引用

页码：317 / 322

页数：6

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