SIMULTANEOUS DETERMINATION OF COMMON BENZODIAZEPINES IN BLOOD USING CAPILLARY GAS-CHROMATOGRAPHY

被引：37

作者：

GJERDE, H ^{[1
]}

DAHLIN, E ^{[1
]}

CHRISTOPHERSEN, AS ^{[1
]}

机构：

[1] NATL INST FORENS TOXICOL,POB 16 GAUSTAD,N-0320 OSLO,NORWAY

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 05期

关键词：

BENZODIAZEPINES; BLOOD; CAPILLARY GAS CHROMATOGRAPHY;

D O I：

10.1016/0731-7085(92)80046-P

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Blood samples were extracted with n-butyl acetate, and the extracts analysed by capillary gas chromatography using DB-1 and DB-1701 capillary columns with electron-capture detection. The DB-1701 column was found to give better separation of different benzodiazepines (BZDs). Recoveries ranged from 79 to 98%. Detection limits ranged from 0.005 to 0.015-mu-M for triazolam and flunitrazepam, and from 0.02 to 0.1-mu-M for other BZDs. Data on accuracy and precision are given for diazepam, desmethyldiazepam, flunitrazepam and nitrazepam.

引用

页码：317 / 322

页数：6

共 50 条

[31] Determination of benzodiazepines in pericardial fluid by gas chromatography-mass spectrometry
Alvarez-Freire, I
Brunetti, P.
Cabarcos-Fernandez, P.
Fernandez-Liste, A.
Tabernero-Duque, M. J.
Bermejo-Barrera, A. M.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 159 : 45 - 52
[32] Determination of phytosterol and cholesterol in oil by capillary gas chromatography
Bao, ZD
Xu, RN
Zhang, SH
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2002, 30 (12) : 1490 - 1493
[33] Simultaneous determination of benzodiazepines in whole blood or serum by HPLC/DAD with a semi-micro column
El Mahjoub, A
Staub, C
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 23 (2-3) : 447 - 458
[34] Simultaneous separation of perfluorocarbons and oxyfluorocarbons using capillary gas chromatography: analysis of the products of hexafluoropropene oxidation
D. Lokhat
D. Ramjugernath
M. Starzak
Journal of Analytical Chemistry, 2014, 69 : 98 - 103
[35] Simultaneous separation of perfluorocarbons and oxyfluorocarbons using capillary gas chromatography: analysis of the products of hexafluoropropene oxidation
Lokhat, D.
Ramjugernath, D.
Starzak, M.
JOURNAL OF ANALYTICAL CHEMISTRY, 2014, 69 (01) : 98 - 103
[36] SORPTION PROPERTIES OF HETEROCYCLIC-COMPOUNDS DIFFERING BY HETEROATOM IN CAPILLARY GAS-CHROMATOGRAPHY
MISHARINA, TA
GOLOVNYA, RV
BELETSKY, IV
RUSSIAN CHEMICAL BULLETIN, 1993, 42 (07) : 1167 - 1170
[37] RAPID ANALYSIS BY CAPILLARY GAS-CHROMATOGRAPHY OF THINNERS AND THE RELATED ORGANIC-SOLVENTS
TAKEKOSHI, Y
SATO, K
KANNO, S
KAWASE, S
KIHO, T
UKAI, S
JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1995, 41 (03): : 227 - 233
[38] COMPARISON OF DIFFERENT SAMPLE PREPARATION METHODS FOR BACTERIA IDENTIFICATION BY CAPILLARY GAS-CHROMATOGRAPHY
WEBER, L
HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, 1990, 13 (12): : 851 - 854
[39] DETERMINATION OF METHYL-BROMIDE RESIDUES IN STORED FOODS USING AUTOMATED HEADSPACE GAS-CHROMATOGRAPHY
NORMAN, KNT
SCUDAMORE, KA
MATTHEWS, WA
WILSON, MF
PESTICIDE SCIENCE, 1995, 44 (04): : 309 - 316
[40] ON-COLUMN ATOMIC-EMISSION DETECTION IN CAPILLARY GAS-CHROMATOGRAPHY USING A RADIO-FREQUENCY PLASMA
PEDERSENBJERGAARD, S
GREIBROKK, T
JOURNAL OF MICROCOLUMN SEPARATIONS, 1994, 6 (01) : 11 - 18

← 1 2 3 4 5 →