EFFECTS OF THE HYPNOTIC DRUG ETOMIDATE IN A MODEL NERVOUS-SYSTEM (BUCCAL GANGLIA, HELIX-POMATIA)

被引：25

作者：

ALTRUP, U ^{[1
]}

LEHMENKUHLER, A ^{[1
]}

SPECKMANN, EJ ^{[1
]}

机构：

[1] INST PHYSIOL,W-4400 MUNSTER,GERMANY

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1991年 / 99卷 / 03期

关键词：

D O I：

10.1016/0742-8413(91)90290-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Effects of the hypnotic drug etomidate were studied with intracellular recordings of the identified neurons B1 to B4 of the buccal ganglia of Helix pomatia. 2. At threshold doses of 10-mu-mol/l, etomidate mainly affected interneuronal networks. 3. In concentrations above 200-mu-mol/l, the drug induced typical epileptic activities (paroxysmal depolarization shifts, PDS). Neurons B1 to B4 generated epileptic activities in differential concentration ranges. PDS were synchronized via electrical contacts. PDS could be blocked by the "calcium antagonist" verapamil but not by a block of chemical synaptic transmission. 4. In comparison with the epileptogenic drug pentylenetetrazol, effective doses of etomidate to induce PDS were about 100 times lower.

引用

页码：579 / 587

页数：9

共 35 条

[1] EFFECTS OF EXTRACELLULARLY APPLIED PROTEOLYTIC-ENZYMES (PRONASE) ON ELECTRO-PHYSIOLOGICAL ACTIVITIES OF IDENTIFIED NEURONS IN THE BUCCAL GANGLIA OF HELIX-POMATIA L [J].