The Orbital Fibroblast: A Key Player and Target for Therapy in Graves' Ophthalmopathy

被引：29
|
作者：
van Steensel, Leendert [1 ]
Dik, Willem A. [1 ]
机构：
[1] Erasmus MC, Dept Immunol, POB 2040, NL-3000 CA Rotterdam, Netherlands
来源：
ORBIT-AN INTERNATIONAL JOURNAL ON ORBITAL DISORDERS AND FACIAL RECONSTRUCTIVE SURGERY | 2010年 / 29卷 / 04期
关键词：
Graves' Ophthalmopathy; Orbital fibroblast; PDGF; Therapy; Pathogenesis;
D O I：
10.3109/01676831003668443
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Orbital fibroblasts play a key role in the pathogenesis of Graves' ophthalmopathy (GO). We discuss some major aspects by which orbital fibroblasts contribute to GO and the important role of PDGF-BB herein. Finally, we propose the orbital fibroblast, and especially the PDGF system acting on orbital fibroblasts, as an important therapeutic target in GO.
引用
收藏
页码：202 / 206
页数：5
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