ENDOMETRIAL LESIONS IN PATIENTS UNDERGOING TAMOXIFEN THERAPY

被引：126
作者：
DEMUYLDER, X
NEVEN, P
DESOMER, M
VANBELLE, Y
VANDERICK, G
DEMUYLDER, E
机构：
[1] Department Obstetrics and Gynecology, Clinique Générale Saint-Jean, B-1000 Brussels, 114, rue du Marais
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 1991年 / 36卷 / 02期
关键词：
TAMOXIFEN; ENDOMETRIAL CARCINOMA; HYSTEROSCOPY; BREAST CANCER;
D O I：
10.1016/0020-7292(91)90767-Y
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Forty-six nonhysterectomized women treated with tamoxifen during 6-36 months as adjuvant therapy for breast cancer underwent a hysteroscopy to assess the endometrial effects of this drug. Whereas the endometrium was normal among 23 patients, 13 presented with endometrial polyps, 8 with hyperplasia and 2 with adenocarcinoma. The rate of endometrial lesions was directly related to the cumulative dose of tamoxifen but it was not statistically different among patients receiving progestational therapy compared to patients who did not receive this therapy.
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页码：127 / 130
页数：4
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