GROWTH-HORMONE INCREASES THE BURSTING STRENGTH OF COLONIC ANASTOMOSES - AN EXPERIMENTAL-STUDY IN THE RAT

被引：30

作者：

CHRISTENSEN, H

OXLUND, H

LAURBERG, S

机构：

[1] Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus

[2] Institute of Experimental Clinical Research, University of Aarhus, Aarhus Kommunehospital, Aarhus

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 1990年 / 5卷 / 03期

关键词：

D O I：

10.1007/BF00300401

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of growth hormone on the bursting strength of left colonic anastomoses was investigated experimentally. Seventy-two 3 month-old female rats were randomized into two groups receiving daily injection of either saline (controls) or 2.0 mg biosynthetic human growth hormone per kg body weight per day. All injections were started 7 days before a left colonic resection and anastomosis, and continued until sacrifice at the 2nd, 4th or 6th post-operative day. The bursting strength of the anastomoses was tested in anaesthetized, living rats. The bursting pressure and the bursting wall tension of the growth hormone treated animals were increased two-fold on the second post-operative day (2 p<0.005) and three-fold on the fourth post-operative day (2 p<0.05), compared with controls. There was no difference in the bursting pressure or the bursting wall tension on the sixth postoperative day. The mass of the resected segment was incresed by the pre-operative growth hormone treatment, whereas the hydroxyproline content was unchanged. In conclusion, treatment with biosynthetic human growth hormone increases the strength of colonic anastomoses in the early phases of healing. © 1990 Springer-Verlag.

引用

页码：130 / 134

页数：5

共 27 条

[1]

Goligher J.C., Graham N.G., DeDombal F.T., Anastomotic dehiscence after anterior resection of rectum and sigmoid, Br J Surg, 57, pp. 109-118, (1970)

[2]

Debas H.T., Thoon F.B., A critical review of colectomy with anastomosis, Surg Gynecol Obstet, 135, pp. 747-752, (1972)

[3]

Ravo B., Colorectal anastomotic healing and intracolonic bypass procedure, The surgical clinics of North America, pp. 1267-1294, (1988)

[4]

Fielding L.P., Steward-Brown S., Blesovsky L., Kearney G., Anastomotic integrity after operations for large-bowel cancer: a multicenter study, Br Med J, 281, pp. 411-414, (1980)

[5]

Dunphy J.E., The cut gut, Am J Surg, 19, pp. 1-8, (1970)

[6]

Foster M.E., Leaper D.J., The alimentary tract, Wound healing for surgeons, pp. 161-179, (1984)

[7]

Schrock T.R., Deveney C.W., Dunphy J.E., Factors contributing to leakage of colonic anastomoses, Ann Surg, 177, pp. 513-518, (1973)

[8]

Cronin K., Jackson D.S., Dunphy J.E., Changing bursting strength and collagen content of the healing colon, Surg Gynecol Obst, 126, pp. 747-753, (1968)

[9]

Stromberg B.V., Klein L.R., Collagen formation during the healing of colonic anastomoses, Dis Colon Rectum, 25, pp. 301-304, (1982)

[10]

Wise L., McAlister W., Stein T., Schuck P., Studies on the healing of anastomoses of small and large intestine, Surg Gynecol Obst, 141, pp. 189-194, (1975)

← 1 2 3 →