SINGLE CHAIN ANTIBODY VARIABLE REGIONS

被引：104

作者：

BIRD, RE

WALKER, BW

机构：

[1] Molecular Oncology, Inc., Gaithersberg, MD 20878

[2] Rockville, MD 20853

来源：

TRENDS IN BIOTECHNOLOGY | 1991年 / 9卷 / 04期

关键词：

D O I：

10.1016/0167-7799(91)90044-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The use of antibodies or antibody fragments for targeting tumors (either for tumor imaging or a carriers for drugs or toxins), has encountered problems of clearance, and non-specific or inefficient binding in clinical trails. A novel approach, linking two antibody variable fragments (Fvs), with a short peptide to generate a continuous polypeptide chain, may be able to overcome some of these problems. Since these single chain antibody variable regions (scFvs), are transcribed from constructed 'genes', large-scale production in, for example, E. coli, should be straightforward.

引用

页码：132 / 137

页数：6

共 43 条

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