Nanotechnology-based inhalation treatments for lung cancer: state of the art

被引:134
作者
Ahmad, Javed [1 ]
Akhter, Sohail [2 ,3 ]
Rizwanullah, Md [1 ]
Amin, Saima [1 ]
Rahman, Mahfoozur [4 ]
Ahmad, Mohammad Zaki [5 ]
Rizvi, Moshahid Alam [6 ]
Kamal, Mohammad A. [7 ]
Ahmad, Farhan Jalees [1 ,2 ]
机构
[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut, New Delhi, India
[2] Jamia Hamdard, Fac Pharm, Nanomed Res Lab, New Delhi, India
[3] Univ Orleans, CBM, CNRS, UPR4301, Rue Charles Sadron, F-45071 Orleans 2, France
[4] Abhilashi Coll Pharm, Dept Pharmaceut, Mandi, HP, India
[5] Najran Univ, Dept Pharmaceut, Coll Pharm, Najran, Saudi Arabia
[6] Jamia Millia Islamia, Dept Biosci, New Delhi, India
[7] King Abdulaziz Univ, Metabol & Enzymol Unit, King Fahd Med Res Ctr, Jeddah, Saudi Arabia
关键词
nanoparticles; lung cancer; inhalational chemotherapy; drug targeting; nanotoxicity;
D O I
10.2147/NSA.S49052
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Considering the challenges associated with conventional chemotherapy, targeted and local delivery of chemotherapeutics via nanoparticle (NP) carriers to the lungs is an emerging area of interest. Recent studies and growing clinical application in cancer nanotechnology showed the huge potential of NPs as drug carriers in cancer therapy, including in lung carcinoma for diagnosis, imaging, and theranostics. Researchers have confirmed that nanotechnology-based inhalation chemotherapy is viable and more effective than conventional chemotherapy, with lesser side effects. Recently, many nanocarriers have been investigated, including liposomes, polymeric micelles, polymeric NPs, solid lipid NPs, and inorganic NPs for inhalation treatments of lung cancer. Yet, the toxicity of such nanomaterials to the lungs tissues and further distribution to other organs due to systemic absorption on inhalation delivery is a debatable concern. Here, prospect of NPs-based local lung cancer targeting through inhalation route as well as its associated challenges are discussed.
引用
收藏
页码:55 / 66
页数:12
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