BLOOD-FLOW AND METABOLIC MICROENVIRONMENT OF BRAIN-TUMORS

被引：29
作者：
VAUPEL, P
机构：
[1] Department of Physiology and Pathophysiology, Pathophysiology Division, University of Mainz, Mainz, D-55099
来源：
JOURNAL OF NEURO-ONCOLOGY | 1994年 / 22卷 / 03期
关键词：
METABOLIC MICROENVIRONMENT; BLOOD FLOW; OXYGENATION; PH; ENERGY STATUS;
D O I：
10.1007/BF01052931
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Summarizing these in vivo data in the context of brain tumor therapy, the following aspects are of particular importance: Low and heterogeneous tumor blood flow may - in addition to the limiting effects of the blood-brain barrier - result in compromised delivery of drugs from blood to the tissue. Low tumor pO2 reduces sensitivity to standard radiation and 'O2-dependent' anticancer drugs. Treatment efficacy may be further altered by changes of tumor pH. Particularly acidosis can decrease radiation sensitivity and modulate the cytotoxicity of anticancer drugs. In the following presentations, these aspects will be discussed regarding in vivo data obtained with positron emission tomography. © 1994 Kluwer Academic Publishers.
引用
收藏
页码：261 / 267
页数：7
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