MECHANISMS OF DIABETIC NEPHROPATHY

被引：30
作者：
HOSTETTER, TH
机构：
[1] Department of Medicine, University of Minnesota, Minneapolis, Minnesota
来源：
AMERICAN JOURNAL OF KIDNEY DISEASES | 1994年 / 23卷 / 02期
关键词：
DIABETIC NEPHROPATHY; RENAL FAILURE; DIABETES;
D O I：
10.1016/S0272-6386(12)80970-X
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes leads to end-stage renal disease in a considerable fraction of patients. A number of risk factors for this process can be identified. These include glycemic control, familial and ethnic risks, and hemodynamic alterations in both systemic and intrarenal hypertension. This latter category of hemodynamic risks may interact with metabolic and genetic influences to ultimately produce progressive diabetic nephropathy. However, manipulation of these vascular stresses by anti hypertensive therapy presently offers the most efficacious means of influencing the progression and perhaps even clinical appearance of diabetic nephropathy. © 1994, National Kidney Foundation. All rights reserved. All rights reserved.
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页码：188 / 192
页数：5
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