EFFECT OF AGE ON THE ACTIVITY OF CERULOPLASMIN OF HUMAN BLOOD

被引：7
作者：
SEMSEI, I
JENEY, F
FULOP, T
机构：
[1] DEBRECEN UNIV MED,SCH MED,DEPT INTERNAL MED 1,H-4012 DEBRECEN,HUNGARY
[2] DEBRECEN UNIV MED,SCH MED,CENT RES LAB,H-4012 DEBRECEN,HUNGARY
来源：
ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1993年 / 17卷 / 02期
关键词：
CERULOPLASMIN; AGING; COPPER CONTENT; IONIC STRENGTH; BLOOD;
D O I：
10.1016/0167-4943(93)90044-I
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aminoxidase activity of ceruloplasmin was measured in the serum of 120 people (between 45 and 102 years of age) using the p-phenylenediamine method. A negative linear age-correlation (-30% for the whole lifespan; P < 0.01) was established in this activity with increasing age, nevertheless the total copper content of blood did not change in the same age-range as measured by an atomic absorption spectrophotometric method. Increasing ionic strength, in vitro, caused an exponential decline in blood ceruloplasmin aminoxidase activity of both middle aged and elderly subjects. The age-dependent decrease in ceruloplasmin activity could have a negative effect on the antioxidant functions of blood, and finally on the aging process itself.
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收藏
页码：123 / 130
页数：8
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