CARDIAC GLYCOSIDE-INDUCED ELEVATION OF INTRACELLULAR NA+ ION CONCENTRATION IN HUMAN ERYTHROCYTES STUDIED BY NA-23 NMR-SPECTROSCOPY - RELATIONSHIP BETWEEN INOTROPY SPEED AND ELEVATION RATE OF INTRACELLULAR NA+ ION CONCENTRATION

被引：0

作者：

TANASE, T ^{[1
]}

MURAKAMI, N ^{[1
]}

NAGATSU, A ^{[1
]}

SAKAKIBARA, J ^{[1
]}

机构：

[1] NAGOYA CITY UNIV, FAC PHARMACEUT SCI, 3-1 TANABE DORI, MIZUHO KU, NAGOYA, AICHI 467, JAPAN

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1993年 / 16卷 / 04期

关键词：

CARDIAC GLYCOSIDE; NA-23 NMR SPECTROMETRY; PROSCILLARIDIN; INOTROPY SPEED; ERYTHROCYTE;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin (1) , and its four derivatives (2-5) was measured using Na-23 NMR spectrometry. In this examination, there was a significant correlation between the time to half maximum inotropic effect and the time to maximum of Na+ concentrations in human erythrocyte, determined by Na-23 NMR.

引用

页码：431 / 433

页数：3

共 5 条

[1] RESPONSE OF THE NA-23-NMR DOUBLE-QUANTUM FILTERED SIGNAL TO CHANGES IN NA+ ION CONCENTRATION IN MODEL BIOLOGICAL SOLUTIONS AND HUMAN ERYTHROCYTES
TAUSKELA, JS
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BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1158 (02) : 155 - 165
[2] A COMPARISON OF INTRACELLULAR SODIUM-ION CONCENTRATIONS IN NEOPLASTIC AND NONNEOPLASTIC HUMAN-TISSUE USING NA-23 NMR-SPECTROSCOPY
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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 508 : 149 - 163
[3] Na+/Ca2+ exchanger contributes to asterosap-induced elevation of intracellular Ca2+ concentration in starfish spermatozoa
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[4] NA-23 NMR ANALYSIS OF HUMAN WHOLE-BLOOD, ERYTHROCYTES, AND PLASMA - CHEMICAL-SHIFT, SPIN RELAXATION, AND INTRACELLULAR SODIUM CONCENTRATION STUDIES
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[5] Amphotericin B-Induced Renal Tubular Cell Injury Is Mediated by Na+ Influx through Ion-Permeable Pores and Subsequent Activation of Mitogen-Activated Protein Kinases and Elevation of Intracellular Ca2+ Concentration
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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (04) : 1420 - 1426

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