TREATMENT OF SYSTEMIC VASCULITIS WITH POOLED INTRAVENOUS IMMUNOGLOBULIN

被引：259

作者：

JAYNE, DRW

DAVIES, MJ

FOX, CJV

BLACK, CM

LOCKWOOD, CM

机构：

[1] IPSWICH HOSP,DEPT MED,IPSWICH,SUFFOLK,ENGLAND

[2] NORTHAMPTON GEN HOSP,DEPT MED,NORTHAMPTON NN1 5BD,ENGLAND

[3] ROYAL FREE HOSP,DEPT RHEUMATOL,LONDON,ENGLAND

来源：

LANCET | 1991年 / 337卷 / 8750期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0140-6736(91)92797-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The therapeutic effect of a course of high-dose, pooled, intravenous immunoglobulin (IVIg) on disease activity and circulating antineutrophil cytoplasm antibodies (ANCA) was investigated in 7 patients with systemic vasculitis. 5 had active disease despite conventional immunosuppression, and 2 had not received any treatment. All 7 had clinical improvement, which was sustained in 6 and transient in 1. The fall in ANCA concentrations to a mean of 51% of the pre-treatment values was maintained during follow-up. C-reactive protein concentration also dropped considerably. IVIg seemed to confer a useful therapeutic effect without adverse reaction.

引用

页码：1137 / 1139

页数：3

共 23 条

[1]

BASTA M, 1989, BLOOD, V74, P326

[2] AUTO-REGULATION OF AUTOANTIBODY SYNTHESIS IN MERCURIC-CHLORIDE NEPHRITIS IN THE BROWN NORWAY RAT .2. PRESENCE OF ANTIGEN-AUGMENTABLE PLAQUE-FORMING CELLS IN THE SPLEEN IS ASSOCIATED WITH HUMORAL-FACTORS BEHAVING AS AUTO-ANTI-IDIOTYPIC ANTIBODIES [J].