POTENTIATION OF ETHANOL VIA INTERFERENCE WITH CALCIUM CHANNELS

被引：6

作者：

DEUTSCH, SI ^{[1
]}

KAUSHIK, M ^{[1
]}

HUNTZINGER, JA ^{[1
]}

NOVITZKI, MR ^{[1
]}

MASTROPAOLO, J ^{[1
]}

机构：

[1] GEORGETOWN UNIV,SCH MED,DEPT PSYCHIAT,WASHINGTON,DC 20007

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 03期

关键词：

ETHANOL; ANTISEIZURE EFFICACY; VOLTAGE-SENSITIVE CALCIUM CHANNELS; NMDA RECEPTOR; NIMODIPINE; INDOLE-2-CARBOXYLIC ACID; MK-801; D-CYCLOSERINE;

D O I：

10.1016/0091-3057(91)90030-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The relevance of ethanol's ability to inhibit voltage-gated and receptor-gated calcium ion conductance in vitro to its acute effects in intact animals was examined. Specifically, nimodipine (a voltage-sensitive calcium antagonist of the dihydropyridine class), indole-2-carboxylic acid (a competitive antagonist of the strychnine-insensitive glycine binding site), MK-801 (a noncompetitive allosteric antagonist of the NMDA receptor complex), and d-cycloserine (a partial agonist of the strychnine-insensitive glycine binding site) were examined for their ability to alter ethanol's antiseizure efficacy in an incremental electroconvulsive shock paradigm. The results showed that drugs known to interfere with voltage-gated and receptor-gated calcium ion conductance potentiated ethanol's antiseizure efficacy. These results implicate voltage-gated and receptor-gated calcium ion conductance in ethanol's acute pharmacologic effects in intact animals.

引用

页码：665 / 668

页数：4

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