EXPERIMENTAL-STUDY OF THE POTENTIAL FOR CONTACT SENSITIZATION AND CROSS-REACTION OF IMIDAZOLE ANTIFUNGALS

被引：9

作者：

NISHIOKA, K

KURATA, K

ASAGAMI, C

机构：

[1] Department of Dermatology, Yamaguchi University School of Medicine, Ube, Yamaguchi, 755

来源：

CONTACT DERMATITIS | 1991年 / 25卷 / 01期

关键词：

IMIDAZOLE ANTIFUNGALS; MICONAZOLE NITRATE; CROCONAZOLE HYDROCHLORIDE; OXICONAZOLE NITRATE; CONTACT SENSITIVITY; CROSS-REACTION; GUINEA PIG SENSITIZATION;

D O I：

10.1111/j.1600-0536.1991.tb01771.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We examined the potential for contact sensitization of miconazole nitrate and croconazole hydrochloride and the cross-reaction between them in guinea pigs by the maximization test of Magnusson and Kligman. Contact sensitivity was induced by croconazole hydrochloride in 5 out of 7 animals which, after being injected with 5% croconazole hydrochloride, underwent a closed patch with 25% croconazole hydrochloride. Contact sensitivity was not induced by miconazole nitrate. The 5 animals sensitized to croconazole hydrochloride were tested with 8 other imidazole antifungals and positive reactions were observed to oxiconazole nitrate in 2 of the 5 animals. This response may be a cross-reaction.

引用

页码：39 / 44

页数：6

共 14 条

[1]

FUNAI K, 1979, IYAKUHIN KENKYU, V10, P290

[2]

HAUSEN BM, 1990, AM J CONTACT DERMATI, V1, P25

[3] CONTACT-DERMATITIS FROM TOPICAL IMIDAZOLE ANTIFUNGALS - 15 NEW CASES [J].