STEREOSPECIFIC SYNTHESES OF ERYTHRO AND THREO 5-(1',2'-DIHYDROXYETHYL)-3-ARYL-OXAZOLIDIN-2-ONES

被引：4

作者：

GENET, JP ^{[1
]}

DENIS, A ^{[1
]}

VILAR, A ^{[1
]}

SCHOOFS, AR ^{[1
]}

ALARD, P ^{[1
]}

机构：

[1] CTR RECH DELALANDE,DEPT PHARMACOCHIM,F-92500 RUEIL MALMAISON,FRANCE

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 04期

关键词：

D O I：

10.1016/0040-4039(90)87022-R

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 5-(1′,2′-dihydroxyethyl)3-aryl - oxazolidin-2-ones 2 and 3 as pure threo and erythro diastereomers, analogs inhibitors of the enzyme monoamine oxidase MAO, is achieved in five step sequence from 1,4-dihalogeno-2-butenes (E) or (Z) through a key stereospecific tandem proeess based on a Payne rearrangement followed by a nucleophilic intramolecular cyclization of epoxycarbamates 7. © 1990.

引用

页码：515 / 518

页数：4

共 25 条

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