ONCOGENIC ACTIVATION OF TYROSINE KINASES

被引：122
作者：
RODRIGUES, CA [1 ]
PARK, M [1 ]
机构：
[1] MCGILL UNIV, MONTREAL H3A 1A1, PQ, CANADA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0959-437X(94)90086-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tyrosine kinases comprise the largest group of oncoproteins, a fact that underscores the importance of reversible tyrosine phosphorylation in the regulation of essential cellular functions. Oncogenic activation of tyrosine kinases results in the constitutive activation of what is normally a conditionally regulated enzyme activity. Studies of tyrosine kinase oncoproteins, and a comparison with their corresponding proto-oncogene products, have identified important functional and regulatory domains within these proteins, positive and negative regulators of their enzyme activities and signalling cascades that control cell growth and differentiation.
引用
收藏
页码：15 / 24
页数：10
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