THE DEVELOPMENT OF BEHAVIORAL SENSITIZATION TO APOMORPHINE IS BLOCKED BY MK-801

被引：57
作者：
DRUHAN, JP [1 ]
JAKOB, A [1 ]
STEWART, J [1 ]
机构：
[1] CONCORDIA UNIV,DEPT PSYCHOL,CTR STUDIES BEHAV NEUROBIOL,1455 DE MAISONNEUVE BLVD W,MONTREAL H3G 1M8,QUEBEC,CANADA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 243卷 / 01期
关键词：
SENSITIZATION; NMDA RECEPTORS; DOPAMINE RECEPTOR AGONISTS; APOMORPHINE; MK-801;
D O I：
10.1016/0014-2999(93)90169-I
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), on the development of sensitization to the mixed dopamine receptor agonist, apomorphine were examined. Rats pretreated with MK-801 (0.25 mg/kg) prior to 2.0 mg/kg apomorphine failed to show a progressive sensitization to the activating effect of apomorphine across six preexposure sessions, nor did they show enhanced activity relative to control rats in response to 0.5 mg/kg apomorphine, given alone, during a subsequent test for sensitization. These results support the view that MK-801 interferes with long-term neural changes underlying sensitization to stimulant drugs.
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收藏
页码：73 / 77
页数：5
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