CEREBRAL BLOOD-FLOW AND METABOLISM DURING REPEATED ASPHYXIAS IN NEWBORN PIGLETS - INFLUENCE OF THEOPHYLLINE

被引：0
作者：
GOPLERUD, JM
DELIVORIAPAPADOPOULOS, M
机构：
[1] UNIV PENN,SCH MED,DEPT PEDIAT,PHILADELPHIA,PA 19104
[2] UNIV PENN,SCH MED,DEPT PHYSIOL,PHILADELPHIA,PA 19104
来源：
BIOLOGY OF THE NEONATE | 1994年 / 65卷 / 3-4期
关键词：
ASPHYXIA; APNEA; CEREBRAL BLOOD FLOW; P-31; NMR; NEWBORN;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The effect of theophylline on cerebral blood flow (CBF), oxygen transport, and energy metabolism was investigated during and following brief episodes of asphyxia. CBF was determined by microspheres during control, asphyxia, and recovery with reventilation after a single asphyxia (recovery I) and after 7 repeated asphyxias (recovery II). In addition, cerebral energy metabolism by P-31 NMR spectroscopy and cerebral oxygen consumption (CMRO(2)) in newborn piglets treated with 30 mg/kg theophylline (serum levels 22-25 mu g/ml) were compared with nontreated piglets. Theophylline increased CMRO(2) during recovery I (348 mu mol O-2/min/100 g vs. 144 for non-theophylline) but not during control, asphyxia, or recovery II. There was no significant difference between the theophylline and non-theophylline groups in depletion of phosphoenergetics as measured by P-31 NMR.
引用
收藏
页码：220 / 230
页数：11
相关论文
共 22 条
[11]   THEOPHYLLINE AND CAFFEINE DISPOSITION IN THE NEONATAL PIGLET [J].
KEARNS, GL ;
HILL, DE ;
TUMBELSON, ME .
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1986, 9 (06) :389-401
[12]   INFLUENCE OF ADENOSINE ON CEREBRAL BLOOD-FLOW DURING HYPOXIC HYPOXIA IN THE NEWBORN PIGLET [J].
LAUDIGNON, N ;
FARRI, E ;
BEHARRY, K ;
REX, J ;
ARANDA, JV .
JOURNAL OF APPLIED PHYSIOLOGY, 1990, 68 (04) :1534-1541
[13]   INTRAVENOUS AMINOPHYLLINE AND CEREBRAL BLOOD-FLOW IN PRETERM INFANTS [J].
MCDONNELL, M ;
IVES, NK ;
HOPE, PL .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 1992, 67 (04) :416-418
[14]   THE EFFECT OF THEOPHYLLINE ON REGIONAL CEREBRAL BLOOD-FLOW RESPONSES TO HYPOXIA IN NEWBORN PIGLETS [J].
MCPHEE, AJ ;
MAXWELL, GM .
PEDIATRIC RESEARCH, 1987, 21 (06) :573-578
[15]   CEREBROVASCULAR HEMODYNAMICS DURING AND AFTER RECOVERY FROM ACUTE ASPHYXIA IN THE NEWBORN DOG [J].
MCPHEE, AJ ;
KOTAGAL, UR ;
KLEINMAN, LI .
PEDIATRIC RESEARCH, 1985, 19 (07) :645-650
[16]   AMINOPHYLLINE REDUCES CEREBRAL BLOOD-FLOW IN STABLE, PRETERM INFANTS WITHOUT AFFECTING THE VISUAL EVOKED-POTENTIAL [J].
PRYDS, O ;
SCHNEIDER, S .
EUROPEAN JOURNAL OF PEDIATRICS, 1991, 150 (05) :366-369
[17]   CEREBRAL BLOOD-FLOW AND O-2 METABOLISM AFTER ASPHYXIA IN NEONATAL LAMBS [J].
ROSENBERG, AA .
PEDIATRIC RESEARCH, 1986, 20 (08) :778-782
[18]   AMINOPHYLLINE REDUCES CEREBRAL BLOOD-FLOW VELOCITY IN LOW-BIRTH-WEIGHT INFANTS [J].
ROSENKRANTZ, TS ;
OH, W .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1984, 138 (05) :489-491
[19]   INFLUENCE OF THEOPHYLLINE ON CONCENTRATIONS OF CYCLIC 3',5'-ADENOSINE-MONOPHOSPHATE AND CYCLIC 3',5'-GUANOSINE MONOPHOSPHATE OF RAT-BRAIN [J].
STEFANOVICH, V .
NEUROCHEMICAL RESEARCH, 1979, 4 (05) :587-594
[20]   EFFECT OF AMINOPHYLLINE ON BRAIN BLOOD-FLOW IN THE NEWBORN PIGLET [J].
STONESTREET, BS ;
NOWICKI, PT ;
HANSEN, NB ;
PETIT, R ;
OH, W .
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1983, 6 (04) :248-258
123