MATERNAL SERUM ALPHA-FETOPROTEIN SCREENING - THE NEED TO USE RACE ETHNIC SPECIFIC MEDIANS IN ASIANS

被引：13

作者：

OBRIEN, JE ^{[1
]}

DRUGAN, A ^{[1
]}

CHERVENAK, FA ^{[1
]}

JOHNSON, MP ^{[1
]}

ISADA, NB ^{[1
]}

HALLAK, M ^{[1
]}

EVANS, MI ^{[1
]}

机构：

[1] METPATH INC,TETERBORO,NJ

来源：

FETAL DIAGNOSIS AND THERAPY | 1993年 / 8卷 / 06期

关键词：

MATERNAL SERUM ALPHA-FETOPROTEIN; RACE-SPECIFIC NORM; ASIANS;

D O I：

10.1159/000263854

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives. We questioned whether race-specific databases for maternal serum alpha-fetoprotein (MSAFP) screening should be added to those already available for African-American and white patients. Study design. We analyzed 138,272 MSAFP samples. The geographic origin of the samples was New York metropolitan area. Patients were classified as white, African-American, Hispanic or Asian. The usual adjustments were made and groups compared. Statistical analysis included ANOVA and multiple comparison test. Results. MSAFP values are highest (p < 0.05) for Asians, followed by African-Americans, Hispanics, and whites, although the difference between Hispanic and white was not significant. Conclusions. Four separate databases are definable if specimen quantity is sufficient. Race/ethnic specific databases are more likely to yield the most accurate detection of abnormal MSAFP values, and therefore, fetal anomalies.

引用

页码：367 / 370

页数：4

共 11 条

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