INCREASED INTERLEUKIN-6 MESSENGER-RNA EXPRESSION BY PERIPHERAL BLOOD-T CELLS FROM PATIENTS WITH IGA NEPHROPATHY

被引：14
作者：
NAKAMURA, T [1 ]
EBIHARA, I [1 ]
TAKAHASHI, T [1 ]
YAMAMOTO, M [1 ]
TOMINO, Y [1 ]
KOIDE, H [1 ]
机构：
[1] JUNTENDO UNIV,SCH MED,DEPT MED,DIV NEPHROL,BUNKYO KU,TOKYO 113,JAPAN
来源：
AUTOIMMUNITY | 1993年 / 15卷 / 03期
关键词：
IGA NEPHROPATHY; T-CELL; INTERLEUKIN-6; MESSENGER RNA;
D O I：
10.3109/08916939309019924
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated interleukin 6 (IL-6) mRNA expression in peripheral blood T-cells obtained from 36 patients with IgA nephropathy (IgAN), 36 patients with other glomerulonephritides and 24 healthy age-matched controls. The majority of patients with IgAN had increased IL-6 mRNA expression by their T cells; no IL-6 mRNA was detected in T cells obtained from patients with other glomerulonephritides or normal controls. A positive correlation was noted between the IL-6 mRNA level and quantity of protein excretion in the urine, histopathological findings, and renal function. However, there was no significant correlation between IL-6 mRNA expression and the IgA-immune complex titer, serum IgA level or blood pressure. mRNA levels in T cells obtained from patients with grade III or IV renal histopathological findings were significantly higher than in those with grade I or II histopathology. In addition, mRNA levels in T cells obtained from patients with more than 1.0 g/day proteinuria were markedly higher than those with less than 1.0 g/day proteinuria. We also studied the clinical course of 11 patients with IgAN during hospitalization. The IL-6 mRNA levels in these patients decreased gradually, as did proteinuria, after treatment. These studies suggest that abnormally regulated IL-6 mRNA expression in peripheral blood T cells may be associated with disease activity in IgAN.
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页码：171 / 179
页数：9
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