INCREASED INTERLEUKIN-6 MESSENGER-RNA EXPRESSION BY PERIPHERAL BLOOD-T CELLS FROM PATIENTS WITH IGA NEPHROPATHY

被引：14

作者：

NAKAMURA, T ^{[1
]}

EBIHARA, I ^{[1
]}

TAKAHASHI, T ^{[1
]}

YAMAMOTO, M ^{[1
]}

TOMINO, Y ^{[1
]}

KOIDE, H ^{[1
]}

机构：

[1] JUNTENDO UNIV,SCH MED,DEPT MED,DIV NEPHROL,BUNKYO KU,TOKYO 113,JAPAN

来源：

AUTOIMMUNITY | 1993年 / 15卷 / 03期

关键词：

IGA NEPHROPATHY; T-CELL; INTERLEUKIN-6; MESSENGER RNA;

D O I：

10.3109/08916939309019924

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated interleukin 6 (IL-6) mRNA expression in peripheral blood T-cells obtained from 36 patients with IgA nephropathy (IgAN), 36 patients with other glomerulonephritides and 24 healthy age-matched controls. The majority of patients with IgAN had increased IL-6 mRNA expression by their T cells; no IL-6 mRNA was detected in T cells obtained from patients with other glomerulonephritides or normal controls. A positive correlation was noted between the IL-6 mRNA level and quantity of protein excretion in the urine, histopathological findings, and renal function. However, there was no significant correlation between IL-6 mRNA expression and the IgA-immune complex titer, serum IgA level or blood pressure. mRNA levels in T cells obtained from patients with grade III or IV renal histopathological findings were significantly higher than in those with grade I or II histopathology. In addition, mRNA levels in T cells obtained from patients with more than 1.0 g/day proteinuria were markedly higher than those with less than 1.0 g/day proteinuria. We also studied the clinical course of 11 patients with IgAN during hospitalization. The IL-6 mRNA levels in these patients decreased gradually, as did proteinuria, after treatment. These studies suggest that abnormally regulated IL-6 mRNA expression in peripheral blood T cells may be associated with disease activity in IgAN.

引用

页码：171 / 179

页数：9

共 47 条

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