ISOPROTERENOL IMPAIRS THE RAT CORONARY VASCULATURE - EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITION

被引：3
作者：
ROUX, S
CLOZEL, JP
FISCHLI, W
KUHN, H
机构：
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1992年 / 19卷 / 04期
关键词：
ISOPROTERENOL; ACE INHIBITION; CILAZAPRIL; VASCULAR REMODELING; CORONARY RESERVE; CORONARY BLOOD FLOW; MYOCARDIAL NECROSIS;
D O I：
10.1097/00005344-199204000-00008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The purpose of the present study was to evaluate whether in addition to its myocardial effects, chronic beta-adrenergic stimulation with isoproterenol could modify the coronary vasculature. For this purpose, rats were treated for 2 weeks with isoproterenol, and the hearts were isolated for determination of the minimal coronary vascular resistance under maximal vasodilation and then perfused-fixed for morphometry of the coronary arteries. In addition, because isoproterenol stimulates the reninangiotensin system (RAS), the effects of angiotensin-converting enzyme (ACE) inhibition on the coronary vasculature were assessed. Isoproterenol increased heart weight by 65% and minimal coronary resistance by 55%. This effect was associated with medial thickening in intermediate (32%) and large coronary arterioles (26%). Cilazapril, a long-acting ACE inhibitor, completely prevented the medial thickening induced by isoproterenol and normalized the minimal coronary resistance. We conclude that impairment of the rat coronary vasculature induced by chronic beta-adrenergic stimulation might be in part mediated by activation of the RAS.
引用
收藏
页码：525 / 531
页数：7
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