PRESENCE OF A NOVEL PRIMARY RESPONSE GENE ST2L, ENCODING A PRODUCT HIGHLY SIMILAR TO THE INTERLEUKIN-1 RECEPTOR TYPE-1

被引:187
作者
YANAGISAWA, K [1 ]
TAKAGI, T [1 ]
TSUKAMOTO, T [1 ]
TETSUKA, T [1 ]
TOMINAGA, S [1 ]
机构
[1] JICHI MED SCH,DEPT BIOCHEM 2,3311-1 YAKUSHIJI,MINAMI KAWACHI,TOCHIGI 32904,JAPAN
关键词
INTERLEUKIN-1; RECEPTOR; CELL GROWTH; PRIMARY RESPONSE GENE; IMMUNOGLOBULIN SUPERFAMILY;
D O I
10.1016/0014-5793(93)81333-U
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the course of studying the ST2 gene, which was initially found to be expressed specifically at the G0/G1 transitional state in BALB/c-3T3 cells and was one of the primary response genes, we found another ST2-related mRNA, designated as ST2L, in serum-stimulated BALB/c-3T3 cells in the presence of cycloheximide. Nucleotide sequence analysis of the cloned ST2L cDNA revealed that it had an open reading frame encoding a polypeptide of 567 amino acids. A 5' region (1,028 nucleotides) of ST2L cDNA was identical with the ST2 cDNA, and a unique 3' region encoded a putative transmembrane domain of 24 amino acids and a cytoplasmic domain of 201 amino acids. The ST2 gene product is highly similar to the extracellular portion of IL-1 receptors type 1 and type 2, and the ST2L gene product shows a marked similarity with entire IL-1 receptor type 1.
引用
收藏
页码:83 / 87
页数:5
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