TUNICAMYCIN-INDUCED INHIBITION OF FUNCTIONAL EXPRESSION OF GLUTAMATE RECEPTORS IN XENOPUS OOCYTES

被引：0

作者：

MUSSHOFF, U ^{[1
]}

MADEJA, M ^{[1
]}

BLOMS, P ^{[1
]}

MUSCHNITTEL, K ^{[1
]}

SPECKMANN, EJ ^{[1
]}

机构：

[1] INST EXPTL EPILEPSIEFORSCH,MUNSTER,GERMANY

来源：

NEUROSCIENCE LETTERS | 1992年 / 147卷 / 02期

关键词：

TUNICAMYCIN; N-GLYCOSYLATION; GLUTAMATE RECEPTOR; MEMBRANE CURRENT; XENOPUS-LAEVIS; OOCYTE;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of tunicamycin, a specific inhibitor of N-linked glycosylation, on functional expression of glutamate receptor subtypes were investigated in RNA-injected oocytes. In the presence of tunicamycin the expression of ligand-operated receptors sensitive to kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and quisqualate were completely blocked. The inhibitory effect was reversible after removal of tunicamycin from the culture medium.

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页码：163 / 166

页数：4

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