TRANSLOCATION (14-18) AND (8-22) IN 3 PATIENTS WITH ACUTE-LEUKEMIA LYMPHOMA FOLLOWING CENTROCYTIC CENTROBLASTIC NON-HODGKINS-LYMPHOMA

被引：35
作者：
FIEDLER, W
WEH, HJ
ZELLER, W
FONATSCH, C
HILLION, J
LARSEN, C
WORMANN, B
HOSSFELD, DK
机构：
[1] MED UNIV LUBECK, DEPT HUMAN GENET, LUBECK, GERMANY
[2] INSERM, U301, DEPT MED, F-75005 PARIS, FRANCE
[3] MED UNIV CLIN MUNSTER, MUNSTER, GERMANY
来源：
ANNALS OF HEMATOLOGY | 1991年 / 63卷 / 05期
关键词：
TRANSLOCATION (14-18) AND (8-22); LEUKEMIA; NHL;
D O I：
10.1007/BF01698379
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14;18) and t (8;22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14;18) was present during the first phase of the disease and that acquisition of translocation t (8;22) was accompanied by leukemic transformation.
引用
收藏
页码：282 / 287
页数：6
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