EFFECTS OF 1,25-DIHYDROXYCHOLECALCIFEROL ON CA-47 ABSORPTION IN POSTMENOPAUSAL OSTEOPOROSIS

被引：23
作者：
CANIGGIA, A
VATTIMO, A
机构：
[1] Institute of Clinical Medicine, University of Siena, Siena
来源：
CLINICAL ENDOCRINOLOGY | 1979年 / 11卷 / 01期
关键词：
D O I：
10.1111/j.1365-2265.1979.tb03052.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Measurement of 47Calcium absorption was performed on eleven women with post‐menopausal osteoporosis. The study was repeated after 10 days treatment with 1 μg daily of 1,25(OH)2D3. These patients showed a statistically significant improvement of fractional calcium absorption that was inversely correlated to the basal values. The prompt improvement of the intestinal calcium transport in post‐meno‐pausal osteoporotic women, a few days after the administration of physiological doses of 1,25(OH)2D3 suggests that these patients synthesize inappropriately small amounts of 1,25(OH)2D3 because of their oestrogen deficiency. This could be an important pathogenetic factor in post‐menopausal osteoporosis, as the efficiency of the adaptation of calcium absorption to low calcium intakes is dependent on 1,25(OH)2D3. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：99 / 103
页数：5
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