NEOPLASTIC TRANSFORMATION IN VITRO OF HAMSTER LENS EPITHELIUM BY SIMIAN VIRUS 40

被引：19

作者：

ALBERT, DM

RABSON, AS

GRIMES, PA

VONSALLM.L

机构：

[1] Pathologic Anatomny Branch, National Cancer Institute

[2] Armed Forces Institute of Pathology, Bethesda

来源：

SCIENCE | 1969年 / 164卷 / 3883期

关键词：

D O I：

10.1126/science.164.3883.1077

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.

引用

页码：1077 / &

共 14 条

[1]

ALBERT DM, 1968, INVEST OPHTH VISUAL, V7, P357

[2]

BERMAN LD, 1967, J NATL CANCER I, V39, P847

[3]

BLACK PH, 1966, JNCI-J NATL CANCER I, V37, P495

[4]

DIAMANDOPOULOS GT, 1968, AM J PATHOL, V52, P633

[5]