LOCALIZATION TO CHROMOSOME-10 OF A LOCUS INFLUENCING MORPHINE ANALGESIA IN CROSSES DERIVED FROM C57BL/6 AND DBA/2 STRAINS

被引：83
作者：
BELKNAP, JK
MOGIL, JS
HELMS, ML
RICHARDS, SP
OTOOLE, LA
BERGESON, SE
BUCK, KJ
机构：
[1] OREGON HLTH SCI UNIV, DEPT MED PSYCHOL, PORTLAND, OR 97201 USA
[2] OREGON HLTH SCI UNIV, DEPT BIOCHEM & MOLEC BIOL, PORTLAND, OR 97201 USA
来源：
LIFE SCIENCES | 1995年 / 57卷 / 10期
基金：
美国国家卫生研究院;
关键词：
ANALGESIA; BXD; C57BL/6; DBA/2; OPIOID RECEPTORS; QTL MAPPING;
D O I：
10.1016/0024-3205(95)02040-P
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A quantitative trait locus (QTL) was detected and mapped to proximal chromosome 10 near the markers Mpmv5 and D10Mit51 with a strong influence on morphine-induced analgesia in the BXD recombinant inbred (RI) strains and in an F-2 cross (B6D2F2) between the BXD progenitor strains, C57BL/6 and DBA/2. A LOD score of 3.9 (p<.00002) was seen for analgesia using the hot plate assay. Naloxone Bmax was also associated with this chromosome region in BXD RI mice. The mu opioid receptor gene (Oprm) has recently been mapped to this same chromosome region. The observation that several morphine-related traits and naloxone Bmax appear to be partly determined by this presumed single locus is consistent with the hypothesis that the mu opioid receptor gene, or one of its modulators, is the basis for the QTL.
引用
收藏
页码：PL117 / PL124
页数：8
相关论文
共 29 条
[1]  
Belknap J.K, 1991, GENETIC BASIS ALCOHO, P225
[2]   CHROMOSOME MAPPING OF GENE LOCI AFFECTING MORPHINE AND AMPHETAMINE RESPONSES IN BXD RECOMBINANT INBRED MICE [J].
BELKNAP, JK ;
CRABBE, JC .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 654 :311-323
[3]   EMPIRICAL ESTIMATES OF BONFERRONI CORRECTIONS FOR USE IN CHROMOSOME MAPPING STUDIES WITH THE BXD RECOMBINANT INBRED STRAINS [J].
BELKNAP, JK .
BEHAVIOR GENETICS, 1992, 22 (06) :677-684
[4]   QUANTITATIVE-TRAIT-LOCI (QTL) APPLICATIONS TO SUBSTANCES OF ABUSE - PHYSICAL-DEPENDENCE STUDIES WITH NITROUS-OXIDE AND ETHANOL IN BXD MICE [J].
BELKNAP, JK ;
METTEN, P ;
HELMS, ML ;
OTOOLE, LA ;
ANGELIGADE, S ;
CRABBE, JC ;
PHILLIPS, TJ .
BEHAVIOR GENETICS, 1993, 23 (02) :213-222
[5]   GENETIC DISSOCIATION OF MULTIPLE MORPHINE EFFECTS AMONG C57BL/6J, DBA/2J AND C3H-HEJ INBRED MOUSE STRAINS [J].
BELKNAP, JK ;
NOORDEWIER, B ;
LAME, M .
PHYSIOLOGY & BEHAVIOR, 1989, 46 (01) :69-74
[6]   QUANTITATIVE TRAIT LOCI MAPPING OF 3 LOCI CONTROLLING MORPHINE PREFERENCE USING INBRED MOUSE STRAINS [J].
BERRETTINI, WH ;
FERRARO, TN ;
ALEXANDER, RC ;
BUCHBERG, AM ;
VOGEL, WH .
NATURE GENETICS, 1994, 7 (01) :54-58
[7]   A GENETIC-LINKAGE MAP OF THE MOUSE - CURRENT APPLICATIONS AND FUTURE-PROSPECTS [J].
COPELAND, NG ;
JENKINS, NA ;
GILBERT, DJ ;
EPPIG, JT ;
MALTAIS, LJ ;
MILLER, JC ;
DIETRICH, WF ;
WEAVER, A ;
LINCOLN, SE ;
STEEN, RG ;
STEIN, LD ;
NADEAU, JH ;
LANDER, ES .
SCIENCE, 1993, 262 (5130) :57-66
[8]   ESTIMATION OF GENETIC CORRELATION - INTERPRETATION OF EXPERIMENTS USING SELECTIVELY BRED AND INBRED ANIMALS [J].
CRABBE, JC ;
PHILLIPS, TJ ;
KOSOBUD, A ;
BELKNAP, JK .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1990, 14 (02) :141-151
[9]   GENETIC ANIMAL-MODELS OF ALCOHOL AND DRUG-ABUSE [J].
CRABBE, JC ;
BELKNAP, JK ;
BUCK, KJ .
SCIENCE, 1994, 264 (5166) :1715-1723
[10]  
DARVASI A, 1993, GENETICS, V134, P943
123